Christine Lucas (Nicole Kidman) wakes up each morning in a bed she doesn’t recognise, in a house that is unfamiliar, with a man she doesn’t know. Every day her husband Ben (Colin Firth) explains that Christine was in a car accident and suffered a brain injury ten years ago which resulted in her having no memory of her life since her early twenties.
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Suspicious of the life she’s living and desperate to reclaim her memory, Christine enlists the help of a neurologist, Dr Nash (Mark Strong). Dr Nash tells Christine that her memory loss occurred following a vicious attack and advises her to start documenting her day-to-day life in secret with a handheld video camera.
As Christine starts to piece together her days and missing memories she soon realises that she can’t trust anyone, especially her husband Ben.